Inhaled Formoterol Diminishes Insulin-Induced Hypoglycemia in Type 1 Diabetes
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Inhaled Formoterol Diminishes Insulin-Induced Hypoglycemia in Type 1 Diabetes
OBJECTIVE Hypoglycemia is one of the major factors limiting implementation of tight glycemic control in patients with type 1 diabetes and is associated with increased morbidity and mortality during intensive insulin treatment. β-2 Adrenergic receptor (AR) agonists have been reported to diminish nocturnal hypoglycemia; however, whether long-acting inhaled β-2 AR agonists could potentially be use...
متن کاملHypoglycemia in Type 1 Diabetes
In subjects with type 1 diabetes, autoimmune destruction of pancreatic -cells leads eventually to an absolute requirement for insulin replacement therapy. Insulin delivered exogenously is not subject to normal physiological feedback regulation, so it may induce hypoglycemia even in the presence of an intact counterregulatory response. The average individual with type 1 diabetes experiences abou...
متن کاملEffects of Acute Insulin-Induced Hypoglycemia on Spatial Abilities in Adults With Type 1 Diabetes
OBJECTIVE To examine the effects of acute insulin-induced hypoglycemia on spatial cognitive abilities in adult humans with type 1 diabetes. RESEARCH DESIGN AND METHODS Sixteen adults with type 1 diabetes underwent two counterbalanced experimental sessions: euglycemia (blood glucose 4.5 mmol/l [81 mg/dl]) and hypoglycemia (2.5 mmol/l [45 mg/dl]). Arterialized blood glucose levels were maintained...
متن کاملEffects of sustained insulin-induced hypoglycemia on cardiovascular autonomic regulation in type 1 diabetes.
Effects of hypoglycemia on cardiac autonomic regulation may contribute to the occurrence of adverse cardiac events. This study assessed the effects of sustained hyperinsulinemic hypoglycemia on cardiovascular autonomic regulation in type 1 diabetic patients and their nondiabetic counterparts. The study consisted of 16 type 1 diabetic patients and 8 age-matched healthy control subjects who under...
متن کاملType 1 Diabetes and Hypoglycemia
Type 1 Diabetes and the -Cell Matthias von Herrath (La Jolla, CA) received the American Diabetes Association (ADA) 2008 Outstanding Scientific Achievement Award for his research on approaches to -cell–specific immune interventions for type 1 diabetes. He began with a discussion of the evidence of a role of viral infections in the development of type 1 diabetes. In experimental models, viral inf...
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ژورنال
عنوان ژورنال: Diabetes Care
سال: 2015
ISSN: 0149-5992,1935-5548
DOI: 10.2337/dc14-2472